Special feature of 1905 film network Jin Hu retired from the old year and Yutu welcomed the new year. A Zi, the actor in the film, and Suo Yabin, a professor at Communication University of China, are the special planning series of Guimao Rabbit Year of Today’s Film Review. At the same time, the director, producer and starring of the film are connected to the scene to talk with you about the biography of Qiao Feng, which is being shown on the Internet.

After Mr. Jin Yong published the novel "Eight Dragons" in 1960s, many TV series, movies, games and animations adapted from it met with you, which influenced audiences from generation to generation. This time, Qiao Feng Biography of Dragon and Eight Branches was made by Donnie Yen, and it is undoubtedly a challenge to make a new work on a work that has been adapted from many classics. Why did Donnie Yen go all out to make this movie?

@ Donnie Yen:I have been filming in this film circle for more than 40 years, and I have filmed all kinds of martial arts films. I hope the theme is different every time. Then why did I shoot "Biography of Qiao Feng" this time? First, I haven’t made a martial arts film in costume for a long time; Secondly, as we all know, Jin Yong’s theme is as high as a mountain, and it is very difficult for you to climb this mountain, which gives me a great motivation in disguise.

During the filming, Donnie Yen only slept for 4 hours every day, and when he got up early every morning, he sent out notices in more than a dozen work groups at the first time, explaining the tasks to be completed today. Liu Yase, who plays A Zi, also sees all this. Similarly, Liu Yase’s role as A Zi also encountered many challenges. Different versions of A Zi before left a deep impression on the audience, and Liu Yase was worried that he could not control the role well.

Before the release, Liu Yase posted a short video on Tik Tok. She appeared in a purple dress with a sword in her hand. Her sword-drawing action made people feel the heroic spirit that A Zi did not have in the past. When asked what impressed Liu Yase most about A Zi, she replied that it was chivalry.

@ Liu Yase:I think Miss A Zi is a person with a very distinct personality. Her aura changes all of a sudden, and then she dares to love and hate. There is also a chivalry in her body.

Speaking of Dragon’s Eight Branches, Qiao Feng is the protagonist who has to be mentioned. From the name point of view, The Story of Qiao Feng with Eight Dragons focuses on the story of Qiao Feng. As an action movie fan, Suo Yabin has seen different versions of Dragon, and this time he is satisfied with Qiao Feng played by Donnie Yen.

@ 京京京京京京:(Qiao Feng) The two most famous versions, one is version, and the other is version, are both successful in image-building, but it must be said that they are not action stars. But Qiao Feng in this movie, his action scenes are real. If I have any regrets about this movie, I think it is that there are fewer action scenes.

Donnie Yen hopes that no matter whether he has seen Jin Yong or not, the audience can feel the charm of martial arts through this film. His goal is to find a balance point in the action drama of this film: it is necessary to preserve the classic plot and even moves of the novel "Eight Dragons", such as the eighteen palms of the dragon; At the same time, he made some innovations on the basis of his previous action films. Donnie Yen thinks that the shooting methods and performance methods of many martial arts films have a facelift feeling recently, so he tries his best to try a new language in this film. The scenes of the films are far away, and you can see the movements of the two people and the relationship between them at the same time.

From Donnie Yen, we can also see a chivalrous spirit. He insisted on action drama, and he has been in Do not forget your initiative mind for a long time, offering an action dinner for the audience. Under the influence of the epidemic in recent years, many fans of martial arts films may have been very hungry. This time, The Legend of Qiao Feng with Eight Dragons appeared as an online movie, giving the audience a "hard" dish, so that they can feel the swords and shadows at home.

In the form of an online movie, The Legend of Qiao Feng with Dragon and Eight Branches brings the audience a martial arts film with pure taste, and our familiar characters such as Qiao Feng and A Zi once again appear on the screen with a new look. Liu Yase, on behalf of the cast, offered his best wishes to the audience in tender language, hoping that in the new year, everyone will have rivers and lakes that can live everywhere, and courage to pursue the wind and dream.

　　In recent years, "Wechat business" has developed rapidly, and the mobile phone WeChat "friends circle" is full of various Wechat business products. Under the temptation of high returns, more and more people have devoted themselves to this new industry, which has quickly become a tool for some lawless elements to seize illegal interests. Recently, the Intermediate People’s Court of Jining City, Shandong Province made a final judgment on 19 defendants, sentenced Yun Huan to 13 years in prison for the crime of producing and selling counterfeit drugs, and fined him 3 million yuan. Deng Hewu was sentenced to 11 years in prison for producing counterfeit drugs and fined 500,000 yuan; Ma Jiayi was sentenced to 11 years in prison and fined 2.6 million yuan for selling counterfeit drugs. The other 16 defendants were sentenced to fixed-term imprisonment ranging from one year to six years, and fined ranging from 20,000 yuan to 300,000 yuan.

　　I feel unwell after taking diet pills, and the drug test shows that it contains contraband.

　　At the beginning of March, 2016, Ms. Wang, a citizen of Jining, saw her friend Kan Lihong selling a slimming product called pure Chinese medicine in the WeChat "circle of friends", so she spent 2,400 yuan to buy 10 boxes, and also wanted to make a little money in Wechat business business. In the spirit of being a conscientious salesman, Ms. Wang first tried to take the slimming capsule, but as a result, she was dizzy and almost went to the hospital. With a lingering fear, she took the slimming capsule to the Jining High-tech Zone Public Security Bureau to report the case. After receiving the report, the public security organ attached great importance to it, and immediately sent this slimming product for inspection. According to the experience, the slimming capsule contains sibutramine, which is forbidden to be produced and sold in China by the state, and is recognized as a counterfeit drug.

　　On May 13, 2016, the Public Security Bureau of Jining High-tech Zone launched an investigation into this case of suspected production and sale of toxic and harmful food. After investigation, it was found that the case involved many provinces and places, and the local police worked together to arrest and criminally detain 19 major suspects.

　　All 19 people who arrived at the case confessed to the facts of the crime. Yun Huan, one of the main suspects in this case, was only 23 years old when she was brought to justice, but it was through her overall arrangement that counterfeit drugs formed an organized and large-scale interest chain from production to sales.

　　When the prosecutor in charge of the case was brought to trial, Yun Huan showed great remorse. As she once said in a chat with her agent Ma Jiayi on WeChat: "One day the boat capsized, and my sin was much heavier than yours." Knowing that you are doing something that violates the law, it is too difficult to stop once you see the benefits.

　　Dissatisfied with Wechat business’s meager profit, he created his own so-called "brand"

　　According to Huan Huan’s confession, in 2015, she worked as an agent in a WeChat group that monopolized a certain brand of diet pills. Later, this diet pill was out of stock and was not sold again, so she retired from the group and no longer represented the brand’s products. Idle at home, she began to study how to "make a lot of money" because she accumulated some experience and contacts as a Wechat business, and Yun Huan sensitively smelled the huge business opportunities in Wechat business sales, but she was not satisfied with the meager profit of earning the middle price difference, so she came up with a bold idea — — Decided to create their own brand to sell.

　　As an agent in Wechat business who has worked as a diet pill before, Yun Huan knows the vast market demand of this product and has many ready-made customers at hand, so she decided to start with the familiar diet products. Since October 2015, Huanhuan has fabricated the manufacturer, copied the appearance of the diet pills previously represented, found someone online to design the outer packaging and drug instructions, and sent them to Hong Wei, a Guangdong manufacturer engaged in printing and packaging business through online contact, who is responsible for the packaging of the products. Later, Huanhuan contacted Deng Hewu and others from the Internet to buy a large number of slimming capsules, and asked them to deliver the slimming capsules directly to Hong Wei.

　　Deng Hewu found a fellow countryman to help with powder filling and processing to produce capsules. In order to achieve the effect of losing weight, sibutramine, a contraband that has a slimming effect but is obviously harmful to human health, was added. On the other hand, Hong Wei printed the product packaging, drug instructions and other items, bought medicine bottles online, bottled and packaged the weight-loss capsules received, and a complete assembly line for producing counterfeit drugs was formed.

　　The slimming capsule has been produced, and the next step is to let it enter the market quickly to gain benefits. Hearing that Yun Huan has become a "brand founder", Ma Jiayi offered to be a "director" agent to help him explore the market. Because this slimming capsule is produced with the gimmick of pure Chinese medicine to lose weight green, claiming that it is absolutely harmless and has no side effects, the product has just entered the market, and it has ushered in a good sales start, and the addition of Ma Jiayi has made the brand quickly popular in the "Wechat business" circle. Many customers who want to rely on drugs to lose weight easily believe these "Wechat business" advertisements, and a large number of orders poured in at one time.

　　Crazy development offline, half a year to collect money up to 10 million

　　According to Yun Huan, some small achievements at the beginning didn’t make her complacent. She thought that her "career" had just started, and she needed more channels and ways to sell her slimming capsules. In order to expand brand influence and increase sales at the same time, according to the previous business model in Wechat business, she established a number of WeChat groups to recruit agents offline nationwide, and settled the payment by bank transfer, WeChat payment and Alipay payment remittance. In order to ensure the profit and sales volume, Huanhuan has established strict rules and regulations in the WeChat agent group. According to the different volume of goods, the agents are divided into six levels: director, super, first-class, second-class, third-class and special. The agent price of each level is different, but the retail price of slimming capsules is unified nationwide. In this way, it went offline by development and lived a rich life.

　　At the same time, Ma Jiayi, as a "director" level agent, also began to frantically establish the development offline of WeChat group. Soon, the "Ma Jiayi Team" became the main force in the sales of slimming capsules, and this intertwined team went offline, forming a huge network all over the country. With the increase of drug sales, more and more customers reported to the agent that they had symptoms of dry mouth, insomnia, stomach acid, dizziness, constipation and various physical discomfort after eating capsules, and even more, they were directly sent to the hospital. Kuaihuan and others, who are at the top of the pyramid, are a little panicked, but in order to seek benefits, they don’t stop there. Yun Huan, together with several "director" level agents, began to show up for a large-scale "rumor". Knowing that the product had problems, on the one hand, she privately used a refund to appease a small number of customers who were in serious condition, on the other hand, she trumpeted the phenomenon that some Chinese medicine ingredients in her product would cause dry mouth. When the lower-level agents asked if the product had relevant documents such as national drug inspection, she unanimously responded that they were all being processed, and insisted that slimming capsules were food-grade drugs.

　　Kuaihuan knows that paper can’t cover fire, and if you don’t make adjustments soon, things will be exposed sooner or later. During this period, she did two things. The first thing was to find Ma Jiayi privately to discuss not making drugs and selling slimming juice, and bluntly said that making juice was to clear the relationship with "medicine". However, Ma Jiayi did not realize that the "storm" was coming soon in the voice of external doubts. The second thing is to ask Deng Hewu why the side effects of slimming capsules are getting worse and worse. She said, "Now there is a female teacher who vomited all day and went to the hospital by herself. The doctor said that the lack of potassium is due to slimming drugs. This is terrible and she has to lose money." Deng Hewu asked that this batch of goods be placed and returned to the packaging factory to give him the loose capsules. But at that time, 900,000 slimming capsules had all been sold out.

　　I thought this questioning storm would soon pass, but I didn’t expect a wave of unrest to rise again and again. Ma Jiayi’s off-line Kanlihong’s Wechat business business caught Ms. Wang’s attention. Finally, after Ms. Wang tried the medicine herself, she felt unwell and chose to report the case, and everything was discovered. In this short period of six months, Yun Huan, Ma Jiayi and others have collected nearly 10 million yuan by developing off-line sales of counterfeit drugs.

　　A small slimming capsule involved 19 suspects from production to sales. In May 2016, the Procuratorate of Jining High-tech Zone successively approved the arrest of several suspects suspected of producing and selling counterfeit drugs. After prosecution by the Procuratorate of High-tech Zone, on October 16 of the same year, the court of Jining High-tech Zone made a first-instance judgment on 19 defendants, including Yun Huan, for the crime of producing and selling counterfeit drugs. Four defendants, including Yun Huan, Deng Hewu and Ma Jiayi, were each sentenced to more than 10 years in prison, and the other 15 defendants were sentenced to penalties ranging from one year to seven years. After the verdict was pronounced in the first instance, Yun Huan and others refused to accept the verdict and appealed in court.

　　On January 15, 2017, after a public hearing by the Intermediate People’s Court of Jining City, a final judgment was made on the case of 19 people, including Yun Huan, who produced and sold counterfeit drugs according to law, reducing some fines and the main punishment of individual accomplices, while the rest maintained the first-instance judgment. This case of counterfeiting and selling fakes with a wide range, a large amount of money involved and extremely bad influence finally came to an end.

　　Zhu Xinqing, the prosecutor of Jining High-tech Zone Procuratorate, who undertook the case, said that behind this case, people saw the story of a young woman with a keen business mind who was lured into the whirlpool of greed by money and eventually accompanied by high walls and bars. To engage in activities in Wechat business, we should be sincere, and don’t move any wrong ideas, otherwise we may be on the road of breaking the law and committing crimes. At the same time, as ordinary consumers, we should improve our ability to distinguish the authenticity of goods in the market and not listen to others’ words easily; Once losses occur, we should learn to take up legal weapons to defend our legitimate rights and interests.

Recently, a reporter from The Paper (www.thepaper.cn) learned from a judgment published by China Judgment Document Network that Sun Mingxia, the "first sister of bonds", paid a bribe of RMB 4.5 million to a deputy director-level official in order to successfully underwrite the bonds of many companies in Zhejiang.

This deputy director-level official is Liu Zhiwen, former deputy director of the Finance Department of Zhejiang Development and Reform Commission. The judgment also shows that Sun Mingxia, the "Bond Sister", underwritten corporate bonds in Zhejiang during the nine years (October 2004-October 2013) totaling RMB 63.55 billion.

Sun Mingxia once served as vice president, general manager and president of fixed income department in Hualin Securities, and also served as general manager of fixed income department in Guosen Securities.

Sun Mingxia

Conspiracy to take bribes was sentenced to five years.

The Paper reporter noted that the above judgment was the first instance of criminal judgment, Liu Zhiwen’s husband Wang Yigong’s crime of accepting bribes. This judgment and the first-instance judgment of Li Yuejin, former director of Finance and Finance Department of Zhejiang Development and Reform Commission, were published on the same day of September 9, 2016 on China Judgment Document Network. Both judgments were made by Jinhua Basic Court of Zhejiang Province.

Criminal judgment, the first instance of Wang Yigong’s crime of accepting bribes, showed that the defendant Wang Yigong, a native of Feixian County, Shandong Province, was the legal representative of Zhejiang Aode Purification Engineering Co., Ltd., and was criminally detained by the Zhejiang Provincial Public Security Bureau on July 29, 2014 on suspicion of accepting bribes, and was arrested on August 15 of the same year.

The People’s Procuratorate of jindong district, Jinhua City accused that from 2005 to 2013, Liu Zhiwen, the wife of the defendant Wang Yigong (who successively served as the chief clerk, deputy researcher and deputy director of the Finance and Finance Department of the Zhejiang Development and Reform Commission, handled another case), took advantage of her position to seek benefits for Guoxin Securities Company, Huaxi Securities Company and Hualin Securities Company, where Sun Moujia once worked, and after conspiring with her husband, the defendant Wang Yigong, passed Wang Yigong.

The Paper reporter confirmed that Sun Moujia was a star figure in the bond market, "Bond Sister" Sun Mingxia, through the explanation of Sun Moujia’s employment in Huaxi Securities, Hualin Securities and Guoxin Securities presented by the public prosecution agency in court and the comparison of public information.

The judgment shows that Sun Mingxia served as the managing director of fixed income headquarters in Huaxi Securities from October 2004 to June 2007, engaged in bond issuance and sales; From June 2007 to August 2008, he served as assistant to the president of Hualin Securities; From August 2008 to March 2011, he served as the vice president of Hualin Securities, in charge of the company’s fixed income business; From March 2011 to February 2012, he served as the president of Hualin Securities, in charge of the company’s fixed income headquarters, investment bank headquarters and Beijing office; From June 2012 to October 2013, he served as President of the Fixed Income Division of Guosen Securities.

Criminal judgment, the first instance of Wang Yigong’s bribery crime, showed that it was found through court trial that in the second half of 2008, Hangzhou Zhuolian Investment Consulting Co., Ltd. was established in the name of his brother-in-law, Hu Mou, and a false bond sales consulting agreement was signed with Sun Mingxia. On April 30, 2009, Sun Mingxia remitted RMB 3.5 million from Hualin Securities Company to the account of Hangzhou Zhuolian Investment Consulting Co., Ltd., and later Wang Yigong accepted the above money and used it for the daily operation and family expenses of the companies under his name.

In addition, in the first half of 2010, Wang Yigong opened two accounts in Hangzhou CITIC Bank in the name of his mother. After Liu Zhiwen informed Sun Mingxia, Sun Mingxia transferred 500,000 yuan into the accounts twice on June 3 and August 12 of the same year, and Liu Zhiwen and Wang Yigong accepted them.

On August 4, 2016, the People’s Court of jindong district held that the defendant Wang Yigong conspired with the staff of state organs, knowing that the staff of state organs took advantage of their position to seek benefits for the trustee, but still illegally accepted bribes from others, and the amount was extremely huge. His behavior constituted the crime of accepting bribes, which was a joint crime and should be investigated for criminal responsibility according to law. Defendant Wang Yigong played a secondary and auxiliary role in the joint crime, and was an accessory, so his punishment should be mitigated. According to the law, Wang Yigong was convicted of accepting bribes, sentenced to five years in prison and fined 500,000 yuan.

In order to facilitate bribery, it is suggested that officials register consulting companies.

According to the judgment and public information, Liu Zhiwen, female, was born in July 1968 and is 48 years old. Liu Zhiwen served as the deputy director of the Planning and Economic Commission of Zhejiang Province in 1998, the director of the Finance Department of the Development Planning Commission of Zhejiang Province from 2001 to 2006, the deputy researcher of the Finance Department of the Development and Reform Commission of Zhejiang Province in November 2006, and the deputy director of the Finance Department of the Development and Reform Commission of Zhejiang Province from January 2009 to May 2014, and was specifically responsible for the declaration and duration management of corporate bonds. After May 2014, Liu Zhiwen was transferred to the position of Deputy Director of Social Development Department of Zhejiang Development and Reform Commission until the case was filed in July 2014.

A witness Ding’s testimony presented by the public prosecution agency confirmed that Liu Zhiwen had been in charge of bond-related work during his work in the Finance Department of the Provincial Development and Reform Commission.

The testimony of Sun Mingxia, a witness, confirmed that Sun Mingxia was engaged in bond issuance in a number of securities companies, and went to Zhejiang Province to conduct business in 2005. He was introduced to Liu Zhiwen, who helped him in bond issuance. In order to thank Liu Zhiwen for his help in the process of underwriting bonds and facilitate the transfer of benefits to Liu Zhiwen, Sun Mingxia suggested Liu Zhiwen to register and establish an investment consulting company in 2009.

Liu Zhiwen asked her husband, Wang Yigong, to operate this matter and set up Hangzhou Zhuolian Investment Consulting Co., Ltd. In fact, Zhuolian Company did not provide any services for Hualin Securities. In the name of consulting fees, Sun Mingxia remitted 6.5 million yuan into Zhuolian Company’s account in April 2009 in two installments, of which 3 million yuan was remitted after posting, and the other 3 million yuan was explicitly given to Liu Zhiwen, and the remaining 500,000 yuan was also given to Liu Zhiwen after deducting the transfer tax.

In 2010, after learning that Liu Zhiwen was short of money in buying a house, Sun Mingxia offered to give Liu Zhiwen some money to show his help in his work. Later, according to the account provided by Liu Zhiwen, Sun Mingxia arranged for two transfers totaling RMB 1 million to Liu Zhiwen’s husband’s mother account.

In addition, the above judgment shows that Liu Zhiwen, an accomplice, made statements and excuses, which confirmed that he knew each other in the process of underwriting Hangzhou Development Bond Business in Sun Mingxia. During 2008-2009, Sun Mingxia wanted to underwrite the bonds of Zhejiang Energy Group and Zhejiang Communications Investment Group. Liu Zhiwen recommended Sun Mingxia’s team to the above two units and strived for and coordinated with the National Development and Reform Commission, so that Sun Mingxia could underwrite the above business smoothly and obtain huge profits.

The summary of a group of corporate bonds issued by the public prosecution agency shows that the Reply of the National Development and Reform Commission on the Approval of Zhejiang Energy Group Co., Ltd. to Issue Corporate Bonds in 2009 confirmed that the corporate bonds of Zhejiang Energy Group Co., Ltd. were issued on February 23, 2009, and the fundraising scale was 4.7 billion. The lead underwriter was Hualin Securities. In 2009, the corporate bonds of Hangzhou Urban Construction Investment Group Co., Ltd. were issued on April 14, 2009, and the scale of fund-raising was 2.2 billion. The lead underwriter was Hualin Securities. In 2009, the corporate bonds of Zhejiang Communications Investment Group Co., Ltd. were issued on March 25, 2009, and the fund-raising scale was 3 billion. Hualin Securities was one of the lead underwriters.

The lead underwriters of the bonds issued by the above three companies were all securities companies that Sun Mingxia worked for at that time.

In addition, the 2009 corporate bond sales consultancy agreement of Hangzhou Urban Construction Investment Group Co., Ltd. signed by Hualin Securities and Zhuolian Company confirmed that Hualin Securities agreed to pay a total consultancy fee of RMB 3.5 million to Zhuolian Company.

The above judgment also revealed the corporate bonds underwritten by Sun Mingxia, the first bond sister, in Zhejiang in the past nine years. From October 2004 to June 2007, during Sun Mingxia’s tenure at Huaxi Securities, Huaxi Securities underwritten corporate bonds in Zhejiang totaling 5 billion yuan. From June 2007 to February 2012, during Sun Mingxia’s tenure at Hualin Securities, Hualin Securities underwritten corporate bonds in Zhejiang totaling 37.35 billion yuan. From June 2012 to October 2013, when Sun Mingxia worked in Guosen Securities, Guosen Securities underwritten corporate bonds in Zhejiang totaling 21.2 billion yuan.

　　Focus on domestic innovative drugs

　　"I am like sitting on a false boat, jumping into the sea will die, and I can only let it go. It’s all about confidence. " Professor Huang Wenlin, Chairman of Cancer Center of Sun Yat-sen University and Guangzhou Dabo Biological Products Co., Ltd. (hereinafter referred to as "Dabo Bio"), jokingly described the feeling of insisting on new drug research and development.

　　Fifteen years ago, Huang Wenlin began to develop a new anti-tumor gene therapy drug — — Recombinant human dermatan adenovirus injection. Although this "innovative new drug from the source" has won the gold medal of China invention patent, the phase III clinical trial is nearly completed. But over the years, he has often been troubled by the shortage of funds and made slow progress.

　　Due to the lack of long-term investment mechanism, especially the imperfection of the capital market, the research and development of new drugs in China is difficult, and the industrialization of new drugs is "difficult to produce".

　　I especially hope that the government can light a "fire"

　　"Now, it has invested nearly 80 million yuan. Except for the support of major new drugs and major national science and technology projects, most of them rely on their own ‘ Huayuan ’ 。” In order to support research and development, Huang Wenlin founded Dabo Bio.

　　At the same time, in December 2017, Luxturna, a "direct drug delivery" gene therapy of an American company, was approved for listing. The drug research and development started two years later than Huang Wenlin.

　　Why did the United States start late and go on the market earlier than China for the same type of new drugs?

　　"In the United States, there is a complete R&D investment mechanism to support the research and development of new drugs. In the basic research stage of the laboratory, some enterprises and research institutes provide various funds to support innovative research. Once a product is developed, investors keep coming in. After listing, it has the advantages of product patents and product protection period, and pharmaceutical giants take over. " Huang Wenlin sighed, "But in China, all this is still far away."

　　"I especially hope that in the last mile when new drugs are about to emerge, the government can order them ‘ Fire ’ Guide venture capital funds to enter, so as to burn. " Huang Wenlin sighed.

　　Self-financing can’t afford huge R&D expenses.

　　Long research and development cycle, high investment and high failure rate are the three major pain points of new drug research and development, especially clinical trials.

　　New drug research and development is a "comprehensive project", a class 1 new drug, which needs continuous capital investment from project establishment to listing. "Among all the links, clinical trials are the ones with the longest duration, the largest capital investment and the highest risk." An internal person in charge of a domestic enterprise engaged in new drug research and development said that with the increasingly complicated design of clinical trial projects, the cost of clinical research has also risen.

　　"For innovative drugs, especially Class 1 innovative drugs, to complete all development, only global pharmaceutical giants can do it at present. After completing the early research and development and reaching the stage node, the average company is subject to the huge financial pressure of later research and development, and most of them will wait for the price, transfer the project to a large pharmaceutical company, or cooperate with it for development. " The above-mentioned personnel said that most small and medium-sized pharmaceutical enterprises in China mainly rely on self-financing for R&D, and R&D investment accounts for 4% of total sales on average & mdash; 8%, the investment is more than 20%.

　　In December 2015, Zhongshan Kangfang Biomedical Co., Ltd. (hereinafter referred to as "Kangfang Bio") awarded the global exclusive right to develop and sell its monoclonal antibody drug AK-107 for tumor immunotherapy to global pharmaceutical giant Merck. The former will receive an upfront payment from Merck and a phased payment with a total price of 200 million US dollars, covering development and promotion. In 2017, Kangfang Bio announced the completion of 300 million yuan Series B financing.

　　However, most new drug research and development in China are not as lucky as Kangfang Bio. Talking about the reasons for the cooperation between Kangfang Bio and Merck, Xia Yu, chairman and CEO of Kangfang Bio, said frankly, "The huge investment in new drug research and development is on the one hand, and another important reason is that the field of tumor immunotherapy is a field where top international pharmaceutical giants compete fiercely, and the speed determines success or failure to a great extent." She revealed that at present, not only clinical trials are advancing rapidly, but also research and development is progressing smoothly.

　　"The cooperation model between Kangfang Bio and Merck is a common cooperation model among pharmaceutical companies in the world." She said that the fundamental solution to the difficulties in the research and development of new drugs in China requires the progress and maturity of the pharmaceutical industry in China at all levels, including the improvement of the R&D strength of enterprises, the improvement of the regulatory system, and the real understanding and long-term support of the capital market for the long-term and high-risk research and development of new drugs.

　　Investors are unprofessional and cannot wait for a long period.

　　Once some competitive drugs go to the market, they can easily achieve sales revenue of over 10 billion dollars. Aren’t the big domestic pharmaceutical companies and investors excited about it?

　　"Domestic intellectual property protection is not perfect, enterprises are reluctant to invest huge sums of money, and investors feel that the risk is too great." Huang Wenlin said, "There was once a large domestic pharmaceutical company with 8 billion yuan in its hands. He asked me how to use this money. It’s not that they don’t understand, but they don’t dare. "

　　"From an investment perspective, domestic investors are immature and rarely really focus on investing in new drug research and development." Wang Yuefei, the founding partner of Jianjin Capital, said that a qualified investor should be familiar with the whole chain of drug research and development. "The lack of understanding of the new drug research and development industry, especially the industrialization link, coupled with the lack of mature funds, has led domestic investors to tolerate long-term investment in new drugs."

　　The internal person in charge of the enterprise engaged in new drug research and development mentioned above also said that investment institutions should truly understand the characteristics of the pharmaceutical industry. "If we simply apply the thinking of investing in the Internet, it may be a lose-lose situation."

　　Wang Yuefei has come into contact with many entrepreneurs in the pharmaceutical industry, including scientists. "Most entrepreneurs in the pharmaceutical industry in China have a technical background. The biggest problem is that they are not open-minded enough to control everything." He emphasized that "the success of foreign new drug research and development is better than that of China, because everyone in the R&D chain knows their role and can achieve division of labor and cooperation."

"studious to make progress. The Communist Party of China (CPC) people rely on learning to go today, and they must also rely on learning to go to the future. "

General Secretary of the Supreme Leader attaches importance to learning. Since the 18th National Congress of the Communist Party of China, he has repeatedly emphasized the importance of learning, and regarded learning as an important way for leading cadres to overcome the "skill panic". He advocated the combination of learning and thinking, learning and asking, and learning and using in learning, which reflected a strong sense of problems and distinctive characteristics of taking learning as a resource.

In the past ten years, he has presided over nearly 100 collective studies in the Political Bureau of the Central Committee, or invited experts to give lectures, or personally went to the grassroots level. The learning content involves many major issues facing the party and the country in the new era; In this decade, he visited the Red Revolutionary Holy Land dozens of times and regarded the revolutionary history of China as "the best textbook" and "the best nutrient". In the past ten years, he has always regarded investigation and research as a way to learn and improve, and as the "key" to listen to public opinion, observe people’s feelings and unlock problems. His research footprint has spread all over the country.

Our party has always been a Marxist party that is diligent and good at learning.

I still remember that on November 17th, 2012, the third day after the closing of the 18th CPC National Congress, the 18th the Political Bureau of the Central Committee held its first collective study. Some media commented that the "learning opening" conveyed the new action information of the new central leading collective to inherit and carry forward the party’s learning tradition.

2013年3月1日，中央党校建校80周年庆祝大会暨2013年春季学期开学典礼在北京举行，中共中央总书记、中共中央军委主席最高领袖出席并发表重要讲话。

“我们的干部要上进，我们的党要上进，我们的国家要上进，我们的民族要上进，就必须大兴学习之风，坚持学习、学习、再学习，坚持实践、实践、再实践。”2013年3月1日，最高领袖总书记在中央党校建校80周年庆祝大会暨2013年春季学期开学典礼上特别强调。

这是最高领袖任中共中央总书记后，第一次全面系统地就领导干部的学习问题发表专门讲话，对为什么学、学什么、怎样学等都作了深刻阐述。

十年来，以最高领袖同志为核心的党中央继承和发扬我们党重视学习、善于学习的优良传统，带头学习、率先学习，为不断提高全党的治国理政能力和水平作出了表率。最高领袖总书记主持中央政治局集体学习近百次，每次学习不仅是停留在获取知识层面，更与治国理政的重大决策部署紧密联系。

2014年12月5日，上海自贸试验区区域扩展前夕，最高领袖总书记就加快自由贸易区建设主持十八届中央政治局第十九次集体学习。

On June 24, 2019, shortly after the theme education of "Do not forget your initiative mind, Remember Mission" was launched, General Secretary of the Supreme Leader presided over the 15th collective study of the 19th the Political Bureau of the Central Committee on "Remember initial mission and promote self-revolution".

The year 2021 is the first year of the 14th Five-Year Plan. The theme of the first collective study in this year is: to do a good job in making a good start in China’s development during the 14th Five-Year Plan period.

…………

At the same time, the forms of collective learning in the Political Bureau of the Central Committee are constantly innovating.

On September 30th, 2013, Zhongguancun National Independent Innovation Demonstration Zone Exhibition Center welcomed a group of special visitors. It became the "classroom" for the ninth collective study in the 18th the Political Bureau of the Communist Party of China (CPC) Central Committee.

In more than an hour, the Supreme Leader and other 18th the Political Bureau of the Central Committee comrades watched carefully in the exhibition areas of 3D printing, integrated circuit equipment, biology and health, had a cordial conversation with researchers, and asked about the independent research and development and application of technologies such as additive manufacturing, big data, biochip and quantum communication, and had a vivid "innovation lesson".

At that time, a new round of scientific and technological revolution and industrial transformation was gestating. When hosting the collective study in the conference room of the exhibition center, the General Secretary of the Supreme Leader profoundly pointed out that opportunities are fleeting, and seizing them is an opportunity, while failing to grasp them is a challenge. We must strengthen our sense of hardship, seize and make good use of the opportunity of the new round of scientific and technological revolution and industrial transformation, and we cannot wait, wait and see, or slack off.

In addition to the Political Bureau of the Central Committee’s collective study, since the 18th National Congress of the Communist Party of China, the CPC Central Committee has organized and carried out five times of intensive study and education within the Party, which is rare in a century of party history. In the process of learning and education, party member cadres have experienced ideological remobilization, initial awakening and mission sublimation again and again, which shows the distinctive characteristics of the Communist Party of China (CPC)’s efforts to build a learning party.

As General Secretary of the Supreme Leader said: "If we don’t work hard to improve all aspects of knowledge literacy, unconsciously learn all kinds of scientific and cultural knowledge, and don’t take the initiative to speed up knowledge updating, optimize knowledge structure, and broaden our horizons and horizons, it will be difficult to enhance our skills, and there will be no way to win the initiative, win the advantage and win the future. Therefore, all party comrades, especially leading cadres at all levels, must have a sense of urgency to strengthen their study. "

General Secretary of the Supreme Leader has repeatedly compared the revolutionary history of China to a "textbook".

On July 11th, 2013, it was drizzling in Xibaipo, Hebei. The general secretary who is investigating and guiding the party’s mass line education practice activities in Hebei Province came here.

From Xibaipo Memorial Hall to Mao Zedong’s former residence, and then to the war room of the Central Military Commission and the former site of the Second Plenary Session of the Seventh Central Committee, the General Secretary looked carefully and carefully. In front of pictures and cultural relics, he listened carefully to the staff and asked about the situation from time to time.

"I have been to Xibaipo many times, and every time I come with reverence and go with a lot of thinking." When talking with local county and township cadres, old party member and representatives of the masses, a series of questions reflected the general secretary’s thinking in his study-

"Every time I come to Xibaipo, what I think most is, what are the main considerations for Comrade Mao Zedong to put forward the’ two musts’? Are there any unfathomable things we have learned? The "two musts" are familiar, but under the current situation, can we deeply understand the "two musts" to better guide the current party building? How to carry forward the new situation today? "

At the symposium, the general secretary explained all these issues and profoundly pointed out that "the challenges and problems we are facing are still severe and complicated" and "the’ rushing for exams’ faced by the party is far from over".

Since the 18th National Congress of the Communist Party of China, the General Secretary has set foot on the Red Revolutionary Holy Land several times, seeking his initial heart from the red history, drawing on the wisdom and nutrition of governing the country, and thinking about the Communist Party of China (CPC)’s mission and responsibility.

On June 21, 2017, the General Secretary visited Shanxi. One of the details is impressive. The general secretary flew directly from Beijing to Lvliang, and then drove for one and a half hours to Xingxian.

What is the significance of choosing Xing County as the first stop of Shanxi inspection? From the itinerary of the General Secretary, we can get a glimpse of one thing or two-offering a flower basket to the revolutionary martyrs in the Jin-Sui border area and paying tribute to the revolutionary memorial hall in the Jin-Sui border area. The Revolutionary Memorial Hall in the Jinsui Border Region is located in Caijiaya Village, 7.5 kilometers west of Xingxian County. It was once the base where Marshal He Long and the 120th Division of the Eighth Route Army lived and fought for 11 years.

Here, the general secretary said with deep affection: "Every revolutionary history of our party is a vivid textbook of ideals and beliefs. Comrades of the whole party must not forget their initial intentions and move on, always remember the revolutionary ancestors who shed their blood for national independence and people’s liberation, always maintain the spirit of struggle of the Communist Party of China (CPC) people, always maintain their childlike innocence for the people, and strive to create a better and happier life for the people. "

On September 16th, 2020, General Secretary of the Supreme Leader had a cordial exchange with villagers and tourists in Shazhou Yao Village, Wenming Yao Township, Rucheng County, Chenzhou, Hunan Province.

In the Jinggangshan Revolutionary Martyrs Cemetery in Jiangxi, the general secretary said, "Let the cadres in party member know that the happy life is hard to come by and receive more red gene education"; In the special exhibition hall of "the warmth of half a quilt" in Shazhou Yao Village, Hunan Province, the general secretary stressed that "we should make good use of such red resources, tell good red stories, do a good job in red education, and let the red genes be passed down from generation to generation"; At the memorial hall of Xiangjiang Campaign of Quanzhou Red Army in Guangxi, the general secretary warned the whole party that "no matter how difficult it is, think about the Red Army’s Long March and the bloody battle in Xiangjiang" …

Pieces of land engraved with red memories, like books, provide an inexhaustible spiritual source for the Communist Party of China (CPC) people.

In the eyes of the Supreme Leader General Secretary, "investigation and research is also a process of self-learning and improvement". He once said: "When conducting investigation and study, leading cadres should put down their airs and dive down, go deep into fields and factories and mines, discuss problems with the masses, listen to their voices, feel their emotions, feel their sufferings, sum up their experience and absorb their wisdom."

Whether working in the local or central government, investigation and research is a "key" for the supreme leader to get close to the masses and unlock the problem.

Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has traveled all over the country. We have seen him sitting on the kang, talking with the people at home and asking how warm and cold he is. I have seen him scoop up a scoop of water from his hometown and taste it; I have seen him roll up his trousers and inspect the operation dock in the rain; I have seen him sitting around a square table with cadres and the masses, planning strategies for poverty alleviation and development …

On April 15, 2019, General Secretary of the Supreme Leader sat together with villagers’ representatives, grassroots cadres, poverty alleviation cadres and rural doctors in Huaxi Village, Zhongyi Township, Shizhu Tujia Autonomous County, Chongqing to talk about poverty alleviation.

On April 15, 2019, Huaxi Village, Zhongyi Township, Shizhu Tujia Autonomous County, Chongqing.

Facing the mountain, a square table and several benches, a symposium was held in the yard of Ma Peiqing, a poverty-stricken household. The general secretary said: "I made a special trip to visit the villagers, just to know on the spot whether the’ two guarantees and three guarantees’ have really landed and what other problems are there." He added with a smile: "When I come to Chongqing this time, I will spot-check your point."

When you said something, the villagers rushed to speak. General Secretary of the Supreme Leader listened carefully and interjected from time to time.

After 7 hours, the general secretary made a special trip to a poor village to "dissect sparrows". Leaving Huaxi Village and returning to Chongqing, it was already late at night. The next day, a symposium was held in Chongqing with the theme of "solving the outstanding problem of’ two worries and three guarantees’". At the critical moment of tackling poverty, we should be problem-oriented and make further arrangements to win the fight against poverty.

An unforgettable scene, a touching moment, recorded the footprints of the General Secretary of the Supreme Leader in this decade.

He went far-14 concentrated contiguous areas in the country went one by one to guide poverty alleviation on the spot;

He sees everything-housing, pension, employment, medical care, education, and cares about the people.

He asked in detail-"How much is the annual income?" "How much is it to build a new house?" "Is there enough food to eat?" "How far does the child have to go to school?"

He thought deeply-how to comprehensively deepen the reform, how to make a decisive battle against poverty, how to make precise policies, what shortcomings are there in building ecological civilization, and where are the bottlenecks that restrict innovation-driven development …

"We should worship the people as teachers, learn from them, put down our airs and throw ourselves down … truly find out the problems faced by the masses, reflect their opinions and sum up the experience created by the masses." The general secretary warned leading cadres at all levels and set an example in this way.

What happened to the Three Gorges on the Road?

The ancient poem "and the wind, that has come a thousand miles, beats at the Jade Pass battlements" refers to Jiuquan, Gansu. In order to make use of these abundant power resources, the first large-scale wind power demonstration base in China was built in 2008. This project has been written into the "Eleventh Five-Year" and "Twelfth Five-Year" renewable energy planning, and many people call it "Three Gorges on the Road".

However, in 2015, nearly 40% of wind power generation equipment was restricted, making it the most severely disabled area in China. The wind power base that was built at a cost of hundreds of billions of yuan in that year can only bask in the Gobi Desert. The director of Jiuquan Energy Bureau said that Jiuquan’s entire installed capacity can generate 30 billion kWh of electricity, but now it only generates less than 17 billion kWh.

The wind power project that has stopped now is only the first phase of the overall project of Jiuquan Wind Power Base. Now, the second phase is under construction.

Gansu Jiuquan Kilowatt Wind Power Base Phase I Project

Who is responsible for "abandoning wind and limiting electricity"?

The phenomenon like Jiuquan in Gansu Province also exists to varying degrees in Inner Mongolia, Xinjiang, Jilin and other places with large installed capacity of wind power equipment. According to the statistics of the National Energy Administration, the direct economic losses caused by these stopped wind power equipment exceeded 16 billion yuan.

With the increasingly severe atmospheric control and the trend of replacing thermal power with clean energy, a large amount of clean energy cannot be put into normal use. What are the reasons? CCTV reporters interviewed all relevant personnel:

Staff of wind power base:The electric power department has strict power restriction instructions.

Gansu Electric Power Company:The consumption of new energy can’t be solved by Gansu or Northwest China alone. If you want to send out the extra electricity, you can only rely on long-distance inter-provincial transmission lines. But at present, there is no supporting transmission line.

State Grid:The transmission line is not without, it has been planned for a long time. It is only the slow approval of national energy that has caused this situation. As early as 2010, when Jiuquan Wind Power Base started construction for one year, the State Grid made an early warning: "There will be a serious surplus of clean energy in Gansu" if there are no external transmission lines.

National Energy AdministrationI don’t agree with the problem of lagging approval. In terms of energy management, local consumption is the best. The problem of "abandoning wind and limiting electricity" arises because the local governments are speeding up development and desperately engaged in construction, and the amount of construction exceeds the local absorptive capacity, which is a problem in planning and management.

Wu Shengxue, who is in charge of Jiuquan new energy project planning, disagrees with overcapacity. He said that when building this large wind power base, it must be integrated into the large power grid and used throughout China. It is implementing the national plan to vigorously develop clean energy, energy conservation and emission reduction, and there is no problem of excessive construction. Because the traditional energy has not retreated, the market of clean energy has been squeezed by thermal power, which has caused the present situation. This is a developing problem, which needs assistance from the national level.

"Phase I" is blocked, where is the electricity for "Phase II"?

Not long ago, the National Energy Administration announced that during the Thirteenth Five-Year Plan period, the windmill would be stopped, and various places, including new energy enterprises, also made suggestions and thought of solutions to the problems. Things seem to have a good result here, but in fact, the windmill has not really ended. Now, the second phase of Gansu Jiuquan Wind Power Base is under construction.

Different from the first phase, in order not to let these wind power have nowhere to go, Jiuquan plans to send these new energy sources to Hunan through the long-distance transmission lines under construction by the State Grid, and then to neighboring provinces such as Hubei and Jiangxi.

Is this power transmission plan feasible in reality? The reporter continued to visit relevant departments in Hunan, Hubei and Jiangxi:

Hunan Electric Power Company Power Trading Center:We must first ensure the water and electricity supply in this province, and we cannot sacrifice our own clean energy for the sake of clean energy in other provinces.

Hubei Provincial Development and Reform Commission Electric Power Department:It’s not that any province is short of electricity, so it’s simply a match. This kind of long-distance transmission is not as good as distributed local consumption.

New Energy Department of Jiangxi Energy Bureau:Long-distance power transmission may be very dangerous to our receiving power grid. It will be very dangerous if the power grid collapses and there is a large-scale power outage.

In fact, Hubei, Jiangxi and other places are still launching a large number of coal power generation projects. Because coal prices have fallen to the bottom, thermal power is much cheaper than wind power, so power-deficient provinces would rather build their own coal-fired power projects to solve the power shortage problem than accept foreign wind power. Behind these coal-fired power projects, there are macro considerations such as developing local economy and solving local employment.

Energy layout can’t afford "small abacus"

The national development concept is to gradually replace coal with new energy, but in practice, one side has electricity but no market, and the other side accelerates the construction of coal-fired power plants. What’s wrong with this?

Developing new energy sources and protecting the environment was originally a good thing for the country and the people. Gansu wants to take the opportunity to develop its own wind power base and attract investment; State Grid has seen the opportunity to develop interconnected power grids; In Central China, we want to continue to demand cheap coal to ensure the competitiveness of power enterprises. No one is wrong, but when put together, it’s not right.

Li Junfeng, director of the National Center for Strategic Research and International Cooperation on Climate Change, said that the problem is that our development thinking and behavior are not in step. When the energy supply is divided into administrative regions, it will cause each to solve its own problems and put the rice bowl in its own hands. Consider the interests of your own province, GDP growth, tax growth or employment.

If you want to have a national chess game of electricity consumption, you must have a national chess game of electricity management system. If you want to replace traditional energy with new energy, you must have a decision-making system with this as the first goal. Those departments that play "small abacus" should make way for the "big truth".

First of all, based on the importance of environmental governance, we can no longer simply regard energy projects as a tool to stimulate economic growth, but must plan energy development projects from a global perspective to prevent new traditional energy projects from continuing to occupy the market space of clean energy.

Secondly, the local governance mechanism should be matched with environmental governance as much as possible, and a cross-regional energy construction, utilization and distribution model should be established to solve the restriction of administrative regions on environmental governance, and the big account of environmental governance should also be calculated when calculating local economic accounts.

In fact, what we lack is not wind, wind power or new energy, but what President Xi has repeatedly emphasized: "the driving force for reform".

　　Huitong Finance APP News-On September 18, 2024, Beijing time, the Malaysian palm oil futures market experienced a significant rising day. Palm oil contract for benchmark December delivery rose 3% to 3,848 ringgit (US$ 907.12) per ton on the Malaysian Derivatives Exchange (BMD), the highest one-day increase since July 24, 2023. The increase was mainly driven by the strong oil prices of short covering and its competitors.

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